Magnesium Pidolate may be a good form to reduce headaches – Aug 2020

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Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate

by Jeanette A. Maier 1,*,Gisele Pickering 2,Elena Giacomoni 3,Alessandra Cazzaniga 1ORCID andPaolo Pellegrino 3
Nutrients 2020, 12(9), 2660; https://doi.org/10.3390/nu12092660

Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.
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Clipped from PDF

• “A recent observation by Assarzadegan and colleagues [9] indicated that a decrease in magnesium levels in serum increased the odds of acute migraine headaches by a factor of 35 in 40 patients with migraine versus 40 healthy controls, and that magnesium deficiency is an independent risk factor in the incidence of migraines. “
• The duration of 1500 mg daily oral magnesium pidolate treatment needed to normalize serum magnesium levels was investigated by Aloisi and colleagues in a study on 40 children designed to evaluate the correlation between magnesium deficiency and the effect on visual evoked potentials. The analysis showed that a treatment lasting 20 days was sufficient to normalize serum magnesium levels in 90% of treated patients.[68]
• Magnesium pidolate may have high bioavailability [35,36] and good penetration at the intracellular level [37]. Furthermore, magnesium pidolate is able to reverse magnesium deficiency responsible for headaches, even after a short administration period [31], and to prevent pediatric tension-type headaches [38].
• “The Italian Headache Society (SISC) guideline mentions magnesium pidolate supplementation for menstrual migraine and pre-menstrual syndrome patients, but a precise administration schedule has not been established [74]. “
• Magnesium pidolate has high bioavailability and good intracellular penetration [82] and it may reverse the magnesium deficiency responsible for headaches, even after a short administration period. Tissue culture and animal model studies indicate that magnesium pidolate may be slightly more effective than other magnesium salts in crossing the BBB [95], and magnesium in general is believed to exert neuroprotective functions. Further studies on the tissue distribution of magnesium pidolate may help to better understand its specific properties.

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VitaminDWiki - 11 studies in both categories Magnesium and Headache

This list is automatically updated

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VitaminDWiki – Headache contains

48 Headache pages

Cluster Headache, etc.

• Cluster and Migraine headache treatment protocol - Sept 2023
• Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022
• Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022
• Comparing High-dose vitamin D therapies
• Headaches helped by Vitamin D in 7 studies – Jan 2020

21+ VitaminDWiki pages have MIGRAINE in the title
This list is automatically updated

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VitaminDWiki – Headache has the following on metals and migraines

Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal	Migraine	No Migraine	Migraine Ratio
Cadmium	0.36 ug	0.09 ug	4X MORE if increase
Iron	0.97 ug	0.48 ug	2X MORE if increase
Lead	1.48 ug	0.78 ug	2X MORE if increase
Magnesium*	10.6 ug	34.5 ug	3.5X LESS if increase
Zinc*	0.24 ug	5.77 ug	24X LESS if increase

• Note: Both Zinc and Magnesium increase the activation of the Vitamin D Receptor, which allows more vitamin D into cells

Also

• Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 Zinc is mentioned
• Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial - Sept 2020  No such attachment on this page

• Zinc somewhat reduced Migraine in RCT - Sept 2020

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial https://doi.org/10.1186/s12937-020-00618-9 FREE PDF

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Asked Perplexity AI to Compare Magnesium Pidolate with other forms for reducing headaches

Clipped from Feb 2024 answer

• Bioavailability and Absorption: The absorption of magnesium from supplements can vary widely, influenced by the specific magnesium salt (e.g., oxide, citrate, pidolate) and the presence of other dietary factors. While magnesium pidolate is suggested to have high bioavailability, other forms like magnesium citrate are also well-absorbed
• Conclusion Magnesium pidolate may offer advantages in terms of bioavailability and intracellular penetration, which could theoretically make it more effective for reducing headaches compared to forms with lower bioavailability.

Complete answer